Bioactive Small Molecules
Medchemexpress LLC Pyrroloquinoline quinone | 72909-34-3 | MFCD00043125 | 330.21 g/mol | C14H6N2O8 | 50 MG
Pyrroloquinoline quinone (PQQ) is a redox cofactor and microbial metabolite provided as a research-grade powder for biochemical and cellular studies. The material is characterized by CAS 72909-34-3 and molecular formula C14H6N2O8, and is intended for research and analytical applications in the laboratory.
- Redox cofactor useful for biochemical and cellular assays.
- Chemical identity confirmed by CAS number and molecular formula.
- Supplied as a dry powder for ease of storage and handling.
- Intended for research and analytical applications.
- Available in small pack sizes appropriate for laboratory use.
Selleck Chemical LLC AZD8421 E1972-1G
AZD8421 is a potent and highly selective inhibitor of Cyclin-dependent Kinase 2 (CDK2) with an IC50 against CDK2 of 9nM with selectivity over CDK1 CDK4 and CDK6 It also exhibits an anti-proliferative effect effectively inhibits Rb phosphorylation and shows strong activity both as a monotherapy and in combination with CDK4/6 inhibitors in breast and ovarian cancer models
Medchemexpress LLC Dabigatran etexilate | 211915-06-9 | MFCD22422841 | 99.8% | 627.73 | C34H41N7O5 | 10 MG
Dabigatran etexilate is the oral prodrug of the direct thrombin inhibitor dabigatran. Supplied as a solid analytical/research standard, it is intended for laboratory and analytical applications, including assay development and studies of anticoagulant activity.
- Prodrug of dabigatran (direct thrombin inhibitor).
- Intended for analytical and research use.
- High purity suitable for analytical applications.
- White to off-white powder; solid form.
- Recommended storage: powder at -20°C or 4°C; follow product documentation.
Cayman Chemical ODM-203, Purity: ≥98%, CAS: 1430723-35-5, 5 mg
A dual inhibitor of VEGFR and FGFR (IC50s = 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4, respectively); selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 µM; inhibits PDGFRα, PDGFRβ, and DDR1 (IC50s = 35, 169, and 6 nM, respectively), as well as MAP4K4, MINK1, RET, SIK2, YES1, and Tie2 (IC50s = 49, 41, 8, 23, 152, and 174 nM, respectively; inhibits FGFR-dependent proliferation in H1581 lung, SNU-16 stomach, and RT4 bladder cancer cells (IC50s = 104, 132, and 192 nM, respectively) and VEGF-induced tube formation by HUVECs (IC50 = 33 nM); decreases tumor volume in a RT4 mouse xenograft model at 20 and 40 mg/kg; reduces tumor growth and intratumor phosphorylation of FGFR in a SNU-16 mouse xenograft model at 30 mg/kg
Cayman Chemical OGG1-IN-O8, Purity: ≥98%, CAS: 350997-39-6, 10 mg
An OGG1 inhibitor (IC50 = 0.35 µM); selective for OGG1 over NEIL1, NTH1, and Fpg at 50 µM
Medchemexpress LLC HY-103712B 5mg , Samuraciclib (hydrochloride dihydrate) CAS: Purity:>98%
HY-103712B 5mg Samuraciclib (hydrochloride dihydrate) CAS: Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib hydrochloride hydrate inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 µM. Samuraciclib hydrochloride hydrate has anti-tumor effects. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Triflusal, Purity: ≥98%, CAS: 322-79-2, 10 mg
A platelet aggregation inhibitor (IC50s = 48.3 and 693 µM in isolated human whole blood and platelet-rich plasma, respectively); inhibits arachidonic acid-induced TXB2 and PGF1α production (IC50s = 468 and 339 µM, respectively); decreases IgG-ovalbumin immune complex-induced NF-κB nuclear translocation and NO production in isolated rat peritoneal macrophages at 1,000 µM; reduces infarct volume and peri-infarct levels of OX-6 in a rat model of focal ischemia induced by permanent MCAO at 30 mg/kg; reduces increases in APP levels induced by amyloid-β (25-35) in rats at 30 mg/kg
Medchemexpress LLC HY-P9924 5mg , Ixekizumab CAS:1143503-69-8 Purity:>98%
HY-P9924 5mg Ixekizumab CAS: 1143503-69-8 Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A (KD<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ITI214, Purity: ≥98%, CAS: 1642303-38-5, 5 mg
A PDE1 inhibitor (Ki = 0.058 nM); selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 µM); enhances novel object recognition in rats at 3 and 6 mg/kg; increases prefrontal cortex cAMP and cGMP levels in mice at 50 mg/kg; reverses MK-801-induced decreases in spontaneous alteration in the T-maze continuous alternation task in mice at 0.1, 3, and 10 mg/kg
Medchemexpress LLC 1-ethyl-1H-pyrazole-5-carboxylic acid-d5 | 2735654-39-2 | 99.9% | 145.17 | C6H3D5N2O2 | 50 MG
1-Ethyl-1H-pyrazole-5-carboxylic acid-d5 is the deuterium-labeled isotopologue of 1-ethyl-1H-pyrazole-5-carboxylic acid intended for use as an internal standard or tracer in analytical workflows. It has CAS number 2735654-39-2, molecular formula C6H3D5N2O2, molecular weight 145.17, and is supplied at high isotopic purity for research use only.
- Deuterium labeled (d5)
- Intended as an internal standard or tracer for NMR, GC-MS, and LC-MS
- High purity (99.9%)
- Molecular formula C6H3D5N2O2; molecular weight 145.17
- Available as a 50 MG package
- For research use only; not validated for medical applications
Cayman Chemical Dihydrokavain, Purity: ≥98%, CAS: 587-63-3, 5 mg
An analytical reference standard categorized as a kavalactone; has analgesic and anxiolytic properties in mice and G. gallus chicks, respectively; intended for research and forensic applications
Medchemexpress LLC Ethotoin | 86-35-1 | MFCD00072127 | 99.6% | 25 MG
Ethotoin is an orally active anticonvulsant agent used in epilepsy research. It is a hydantoin, similar to phenytoin. It is supplied as a solid, white to off-white in color, with a purity of 99.61%.
Cayman Chemical Isosilybin, Purity: ≥95%, CAS: 72581-71-6, 25 mg
A flavanolignan with antioxidant and anticancer activities; inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM); inhibits the production of ROS, MDA and LDH release, and reduction in total antioxidant capacity induced by Aβ25-35 in HT-22 hippocampal cells; increases protein and mRNA expression of HO-1, GST, AKCR1C1, and AKCR1C2 in HT-22 cells; reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model at 50 and 100 mg/kg; reduces expression of tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phosphor-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor bearing mice
Medchemexpress LLC Phospho-CDK1/2/3 (Thr14) Antibody (YA218) | 100 UL
The Phospho-CDK1/2/3 (Thr14) Antibody (YA218) is a rabbit-derived, non-conjugated IgG monoclonal antibody, specifically designed to target Phospho-CDK1/2/3 (Thr14). This antibody is for research use only, aiding in the study of cell cycle regulation. CDK1/2/3 are pivotal kinases involved in controlling the eukaryotic cell cycle, modulating centrosome dynamics and mitotic onset, and influencing G2-M transitions.
- Rabbit-derived, monoclonal IgG antibody
- Non-conjugated
- Targets Phospho-CDK1/2/3 (Thr14)
- Reactivity with human and hamster species
- Molecular weight: 34 kDa
- Application for Western Blot (WB) at 1:500-1:1000 dilution
- Application for Immunoprecipitation (IP) at 1:20 dilution
- Formulated in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA
Cayman Chemical DLAC, Purity: ≥97%, CAS: 70803-56-4, 250 mg
A detergent used to solubilize membrane proteins; synthesized from lactobionic acid; CMC = 1.3 mM