Bioactive Small Molecules
Medchemexpress LLC HY-Y0136 500mg Medchemexpress, 3-Indoleacetonitrile CAS:771-51-7 Purity:>98%
Medchemexpress, HY-Y0136 500mg 3-Indoleacetonitrile CAS:771-51-7 3-Indoleacetonitrile is an endogenous metabolite. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Navitoclax (ABT-263) 10mM/1mL 923564-51-6
Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ? 0.5 nM, ?1 nM and ?1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC 7-diethylamino-3-thenoylcoumarin | 77820-11-2 | MFCD00051376 | 99.2% | 327.40 g·mol⁻¹ | C18H17NO3S | 250 MG
BioA-IN-1 is a small-molecule inhibitor of BioA, an enzyme in the biotin biosynthesis pathway of Mycobacterium tuberculosis. Reported as compound 15 in the literature, it has an IC50 of 0.195 μM and shows antibacterial activity with no reported cytotoxicity; it is supplied for research use.
- Inhibits BioA enzyme involved in biotin biosynthesis.
- Reported IC50 of 0.195 μM (compound 15).
- Demonstrates antibacterial activity without reported cytotoxicity.
- High reported purity (≈99.2%).
- Chemical formula C18H17NO3S; molecular weight 327.40 g·mol⁻¹.
- Available in small-scale packaging suitable for research (e.g., 250 mg).
Cayman Chemical MTSETchlorIde 5mg
A positively charged sulfhydryl-specific reagent that reacts with substituted-cysteines; used to provide functional information about relative positions of amino acids within a protein and to probe binding site electrostatic interactions
Cayman Chemical ANTIBODY 1-A-N 1mg
An ionizable cationic lipid; has been used in the generation of LNPs for siRNA delivery in vivo; LNPs containing 1-A-N and encapsulating siRNA targeting the gene encoding CD45 reduce its gene expression in splenic T cells in mice
Medchemexpress LLC HY-126682 1mg , Mal-VC-PAB-DM1 CAS:1464051-44-2 Purity:>98%
HY-126682 1mg Mal-VC-PAB-DM1 CAS: 1464051-44-2 Mal-VC-PAB-DM1 is a drug-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker Mal-VC-PAB . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Mito-TEMPO S9733-25MG
Mito-TEMPO (MT) a mitochondria-targeted superoxide dismutase mimetic protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression
AdipoGen Apigenin 7-glucoside (25 mg)
Chemical. CAS: 578-74-5. Formula: C21H20O10. MW: 432.38. Apigenin 7-glucoside is a flavonoid with anti-inflammatory, antioxidant, anticancer, anti-adipogenic and anxiolytic activities. It has been shown to inhibit LPS-induced nitric oxide production in RAW 264.7 cells or have hepatoprotective activity due to it's antioxidant activities, acting as scavengers of ROS. Apigenin 7-glucoside has been shown to have anti-proliferative activity, possible through cell cycle inhibition and consequently induce apoptosis. it also has the ability to enhance melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. Apigenin 7-glucoside has shown neuroprotective effects possibly by inhibiting neuroinflammation and its antioxidant activity. Apigenin-7-O-glucoside inhibits adipogenesis of 3T3-L1 preadipocytes at early stage of adipogenesis at high concentrations, by downregulating PPARgamma and CEBP-alpha.
Cayman Chemical DesmethoxyyngonIn 5mg
An analytical reference standard categorized as a kavalactone; increases the duration of sleep in a mouse model of pentobarbital-induced sleep; intended for research and forensic applications
Sigma Aldrich Fine Chemicals Biosciences Entacapone >=98% (HPLC) | 130929-57-6 | 10MG
Entacapone >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 305.29 | 130929-57-6 | 10MG
Selleck Chemical LLC MIRA-1 E4634-100MG
MIRA-1(NSC 19630) a maleimide compound is a selective inhibitor of Werner syndrome WRN helicase activity with an IC50 of 20 M while sparing ATPase and exonuclease activities It reactivates mutant p53 inducing apoptosis in various human solid tumor cell lines with tetracycline-regulated mutant p53
AdipoGen Prostaglandin E1 (5 mg)
Chemical. CAS: 745-65-3. Formula: C20H34O5. MW: 354.49. Prostaglandin E1 (PGE1) is an endogenous prostaglandin used as a medication. Its synthetic form, alprostadil, is a vasodilator and smooth muscle relaxant used for several different medical purposes. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-gamma-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM. The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.
Selleck Chemical LLC VVD-130037 E4728-25MG
VVD-130037(BAY-3605349) is an orally available covalent small molecule activator of Kelch-like ECH associated protein 1 (KEAP1) which provide enhanced cellular degradation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) resulting in significant inhibition of tumor growth in advanced solid tumors
Selleck Chemical LLC PF-06873600 S8816-5MG
PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2) CDK4 and CDK6 with Ki values of 0 1 1 2 and 0 1 nM respectively blocks the phosphorylation of retinoblastoma protein (RB1) and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM respectively